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J Invest Dermatol 131(10):19811986 Acknowledgments We thank all the technical support of colleagues from Immunogenetics Laboratory of Universidade Federal do Rio Grande do Sul and specially Bruno Paiva dos Santos, Cntia Giongo, Gabriela Kniphoff da Silva, Maurcio Busatto, Nay Balzan Schneider and Tiago Pires Dalberto

Indeed, in the last decade several groups have put forth studies that support the theory that PD originates in the gut and that overtime pathology spreads into the brain